Pregnenolone Carbonitrile

Research use only, not for human use.

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.

Pregnenolone Carbonitrile is an activator of rodent-PXR and induces the expression of CYP3A.(In Vitro):Pregnenolone Carbonitrile is hepatoprotective by increasing resistance to subsequent stressful insults.(In Vivo):In WT mice, Pregnenolone Carbonitrile (40 mg/kg/day; i.p.) induces the expression of CYP3A11 and CYP2B10 at the mRNA, protein, and enzymatic levels. In adult female Sprague-Dawley rats, Pregnenolone Carbonitrile (100 mg/kg; i.p.) induces the expression of CYP3A mRNA. In male Sprague-Dawley rats, Pregnenolone Carbonitrile (35 mg/kg; gavage) increase in Pgp expression.

5-Pregnen-3β-ol-20-one-16α-carbonitrile; Pregnenolone 16α-carbonitrile?

Metabolic Enzyme/Protease

P450

enoyl-acyl carrier protein reductase (FabI);S. aureus

——

——

1434-54-4

341.5

C22H31NO2

>98% (HPLC)

——

C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](O)CC4)[H])[H])(C[C@@H](C#N)[C@@H]2C(C)=O)[H]

——

(-20℃)

With Ice Pack

≥ 2 years